Related Products

Molecular

Species

Protein

Antibody

Application

cDNA ORF Clone  
Cell Lysate  
qPCR
ELISA Pair Set

TREM1

Human

10511-H08H
C-His

10511-RP01
Rabbit IgG Pab

ELISA

10511-T24
Rabbit IgG PAb,Antigen Affinity Purified

/

10511-H03H
C-human IgG1-Fc&His

10511-MM03
Mouse IgG2b Mab

ELISA

10511-MM07
Mouse MAb

/

10511-MM02
Mouse IgG1 Mab

/

10511-MM02-P
Mouse IgG1 Mab(PE)

/

10511-MM04
Mouse MAb

/

TREM1 (triggering receptor expressed on myeloid cells) is a type I  transmembrane protein with a single Ig-like domain, and is selectively expressed on blood neutrophils and a subset of monocytes. As a member of the growing family of receptors related to NK cell receptors, TREM1 activates downstream signaling events with the help of an adapter protein called DAP12. Expression of TREM1 is up-regulated by bacterial LPS, a ligand for TLR4, as well as lipoteichoic acid. Although its natural ligand has not been identified, engagement of TREM1 with agonist mAbs triggers secretion of the proinflammatory cytokines TNF-α and IL-1β, as well as chemokines such as IL-8 and monocyte chemoattractant protein (MCP)-1. Intracellularly, TREM1 induces Ca2+ mobilization and tyrosine phosphorylation of extracellular signal-related kinase 1 (ERK1), ERK2 and phospholipase C-γ. In an animal model of LPS-induced septic shock, blockade of TREM1 signaling inhibited hyperresponsiveness and death. Thus, it has been demonstrated that TREM1 performs a critical function in immune responses involved in host defense against microbial challenges, and is suggested to be a potential therapeutic target for septic shock.