Related Products

Molecular

Species

Protein

Antibody

Application

cDNA ORF Clone  
Cell Lysate  
qPCR
ELISA Kit 
ELISA Pair Set

TREM2

Human

11084-H08H
C-His

11084-RP01
Rabbit IgG PAb

ELISA

11084-MM08
Mouse MAb

/

11084-R016
Rabbit IgG MAb

/

11084-RP02
Rabbit IgG PAb,Antigen Affinity Purified

ELISA

Mouse

50149-M08H
C-His

50149-T16
Rabbit IgG PAb,Antigen Affinity Purified

ELISA

50149-RP01
Rabbit IgG PAb

ELISA

50149-M02H
C-human IgG1-Fc

/

/

Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the basal ganglia, corpus callosum, medulla oblongata and spinal cord, and microglial cells are the major TREM2-producing cell type in the central nervous system (CNS). TREM2 may play a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. TREM2 forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. It also associates with the signal adapter protein, DAP12, which has a cytoplasmic ITAM, leading to the subsequent activation of cytoplasmic tyrosine kinases. TREM2 is both required and sufficient for competent uptake of apoptotic neuronal cells. TREM2 and TREM2-L form a receptor-ligand pair connecting microglia with apoptotic neurons, directing removal of damaged cells to allow repair. Deficiency of the adapter protein DAP12 or its associated receptor TREM2 is associated with abnormal osteoclast development in humans. Defects in TREM2 are causes of PLOSL, also known as NHD. In addition, TREM2 signaling is also an important pathway to promote healing of wounds in the colon where stem cell replacement is necessary.