Related Products

Molecular

Species

Protein

Antibody

Application

cDNA ORF Clone 
qPCR 
ELISA Pair Set

C5a

Human

10604-HNAE
Native&Active

10604-R241
Rabbit IgG Mab

ELISA

10604-MM04
Mouse IgG2b Mab

ELISA

10604-RP01
Rabbit IgG Pab

ELISA

10604-RP02
Rabbit IgG PAb,Antigen Affinity Purified

ELISA

10604-R215
Rabbit IgG Mab

IHC-P

Mouse

51136-MNAE
 Native

90084-RP01
Rabbit IgG Pab

ELISA

90084-T24
Rabbit IgG PAb,Antigen Affinity Purified

ELISA,IHC-P

CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominantly as a monomer on cell surfaces and interacts with two co-stimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus induces the signal pathways which regulate T cell activation and tolerance, cytokine production, and the generation of CTL. It is indicated that contacts between B and T helper cells mediated by CD86 encourage signals for the proliferation and IgG secretion of normal B cells and B cell lymphomas. Recent study has revealed that CD86 also promotes the generation of a mature APC repertoire and promotes APC function and survival. CD86 has an important role in chronic hemodialysis, allergic pulmonary inflammation, arthritis, and antiviral responses, and thus is regarded as a promising candidate for immune therapy.