Related Products

Molecular

Species

Protein

Antibody

Application

cDNA ORF Clone 
Cell Lysate  
qPCR 
ELISA Pair Set 

CA12

Mouse

50014-M08H
C-His&Active

50014-RP02
Rabbit IgG Pab,Antigen Affinity Purified

ELISA,IHC-P

50014-RP01
Rabbit IgG Pab

ELISA

50014-R003
Rabbit IgG Mab

/

50014-R012
Rabbit IgG Mab

ELISA,IHC-P

Human

10617-H08H
C-His&Active

10617-RP02
Rabbit IgG Pab,Antigen Affinity Purified

WB,IHC-P

10617-MM08
Mouse IgG1 Mab

ELISA

10617-MM01
Mouse IgG1 Mab

FCM

10617-MM04
Mouse IgG1 Mab

IF,ICC/IF

10617-MM07-F
Mouse IgG1 Mab

FCM

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes first discovered in 1933 that catalyze the reversible hydration of carbon dioxide. CAs participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. CA12, also known as Car12 and carbonic anhydrase XII, is a type I  membrane enzyme of an N-terminal extracellular catalytic domain, a membrane-spanning α-helix, and a small intracellular C-terminal domain. It is highly expressed in colon, kidney, prostate, intestine and activated lymphocytes and moderately expressed in pancreas, ovary, and testis. Overexpression of the CA12 is observed in certain human cancers and is used as a tumor marker. rmCA12 corresponds to the extracellular domain and has both carbonic anhydrase activity and esterase activity.