Related Products

Molecular

Species

Protein

Antibody

Application

cDNA ORF Clone
Cell Lysate 
qPCR 
ELISA Pair Set 

CD4

Human

10400-H03H
C-human IgG1-Fc&His Active

/

/

10400-H08H
C-His&Active

10400-R104
Rabbit IgG Mab

ELISA,WB

10400-RP01
Rabbit IgG Pab

ELISA

10400-MM08-F
Mouse IgG1 Mab

FCM

10400-RP02
Rabbit IgG PAb,Antigen Affinity Purified

ELISA,WB

10400-MM03
Mouse IgG1 MAb

ELISA

10400-H08H1
C-His&Active

/

/

Ferret

60003-F08H
C-His&Active

60003-MM08
Mouse IgG1 Mab

FCM

60003-MM02
Mouse IgG1 Mab

FCM

60003-R108
Rabbit IgG Mab

ELISA

60003-RP02
Rabbit IgG PAb,Antigen Affinity Purified

ELISA

Rhesus

90274-C08H
C-His

/

/

Rat

80086-R08H
C-His

/

/

Mouse

50134-M08H
C-His&Active

50134-R001
Rabbit IgG MAb

ELISA,IHC-P

50134-RP01
Rabbit IgG Pab

ELISA

50134-T16
Rabbit IgG PAb,Antigen Affinity Purified

ELISA

T-cell surface glycoprotein CD4, is a single-pass type I membrane protein.CD4 contains three Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. CD4 is a glycoprotein expressed on the surface of T helper cells, regulatory T cells, monocytes,macrophages, and dendritic cells. The CD4 surface determinant, previously associated as a phenotypic marker for helper/inducer subsets of T lymphocytes, has now been critically identified as the binding/entry protein for human immunodeficiency viruses (HIV). The human CD4 molecule is readily detectable on monocytes, T lymphocytes, and brain tissues. All human tissue sources of CD4 bind radiolabeled gp120 to the same relative degree; however, the murine homologous protein, L3T4, does not bind the HIV envelope protein. CD4 is a co-receptor that assists the T cell receptor(TCR) to activate its T cell following an interaction with an antigen presenting cell. Using its portion that resides inside the T cell, CD4 amplifies the signal generated by the TCR. CD4 interacts directly with MHC class II molecules on the surface of the antigen presenting cell via its extracellular domain. The CD4 molecule is currently the object of intense interest and investigation both because of its role in normal T-cell function,and because of its role in HIV infection. CD4 is a primary receptor used by HIV-1 to gain entry into host T cells. HIV infection leads to a progressive reduction of the number of T cells possessing CD4 receptors.Viral protein U (VpU) of HIV-1 plays an important role in downregulation of the main HIV-1 receptor CD4 from the surface of infected cells. Physical binding of VpU to newly synthesized CD4 in the endoplasmic reticulum is an early step in a pathway leading to proteasomal degradation of CD4. Amino acids in both helices found in the cytoplasmic region of VpU in membrane-mimicking detergent micelles experience chemical shift perturbations upon binding to CD4, whereas amino acids between the two helices and at the C-terminus of VpU show no or only small changes,respectively. Paramagnetic spin labels were attached at three sequence positions of a CD4 peptide comprising the transmembrane and cytosolic domains of the receptor. VpU binds to a membrane-proximal region in the cytoplasmic domain of CD4.