Related Products

Molecular

Species

Protein

Antibody

Application

cDNA ORF Clone
qPCR
Cell Lysate

CD93/ C1QR1

Human

12589-H02H
C-human IgG1-Fc

/

/

12589-H08H
C-His

12589-RP01
 Rabbit IgG Pab

ELISA

12589-MM01-F
Mouse IgG2a Mab(FITC)

FCM

12589-R004
Rabbit IgG Mab

ELISA

12589-MM01
Mouse IgG2a Mab   

FCM

12589-MM02
Mouse IgG1 Mab   

ELISA

12589-MM01-P
 Mouse IgG2a Mab(PE)

FCM

12589-MM01-A
 Mouse IgG2a Mab

FCM

Rat

80207-R08H
C-His

80207-R164
Rabbit IgG Mab

ELISA

80207-RP01
Rabbit IgG Pab

ELISA

80207-T16
Rabbit IgG Pab, Antigen Affinity Purified

ELISA

CD93 or C1q receptor 1 (C1qR) is an about 120 kDa O-sialoglycoprotein that within the hematopoietic system is selectively expressed on cells of the myeloid lineage. CD93/C1qR is a highly glycosylated transmembrane protein expressed on monocytes, neutrophils, endothelial cells, and stem cells. CD93 was originally identified as a myeloid cell-surface marker and subsequently associated with an ability to modulate phagocytosis of suboptimally opsonized immunoglobulin G and complement particles in vitro. CD93/C1qR, a receptor expressed during early B-cell development, is reinduced during plasma-cell differentiation. High CD93/CD138 expression was restricted to antibody-secreting cells both in T-dependent and T-independent responses as naive, memory, and germinal-center B cells remained CD93-negative. CD93 was expressed on (pre)plasmablasts/plasma cells, including long-lived plasma cells that showed decreased cell cycle activity, high levels of isotype-switched Ig secretion, and modification of the transcriptional network. CD93 is important for the maintenance of plasma cells in bone marrow niches.