Related Products

Molecular

Species

Protein

Antibody

Application

cDNA ORF Clone
Cell Lysate 
qPCR
Immunomagnetic Beads

SIRP alpha/CD172a

Mouse

50956-M02H
C-human IgG1-Fc

/

/

50956-M08H
C-His

50956-R001
Rabbit IgG MAb

ELISA,FCM

50956-R001-A
Rabbit IgG MAb(APC)

FCM

50956-RP01
Rabbit IgG PAb

ELISA

50956-T16
Rabbit IgG PAb    Antigen Affinity Purified

ELISA

50956-R009
Rabbit IgG MAb

ELISA

50956-R001-F
Rabbit IgG MAb(FITC)

FCM

50956-R001-P
Rabbit IgG MAb(PE)

FCM

Rat

80270-R08H
C-His

80270-R001
Rabbit IgG MAb

ELISA

80270-T56
Rabbit IgG PAb    Antigen Affinity Purified

ELISA,WB   IHC-P

80270-RP01
Rabbit IgG PAb

ELISA

Human

11612-H08H
C-His

11612-MM03
Mouse IgG2b PAb

ELISA,WB,FCM

11612-MM03-A
Mouse IgG2b MAb(APC)

FCM

11612-RP01
Rabbit IgG PAb

ELISA

11612-MM03-F
Mouse IgG2b MAb(FITC)

FCM

11612-RP02
Rabbit IgG PAb    Antigen Affinity Purified

ELISA,IP

11612-MM03-P
Mouse IgG2b PAb(PE)

FCM

CD93 or C1q receptor 1 (C1qR) is an about 120 kDa O-sialoglycoprotein that within the hematopoietic system is selectively expressed on cells of the myeloid lineage. CD93/C1qR is a highly glycosylated transmembrane protein expressed on monocytes, neutrophils, endothelial cells, and stem cells. CD93 was originally identified as a myeloid cell-surface marker and subsequently associated with an ability to modulate phagocytosis of suboptimally opsonized immunoglobulin G and complement particles in vitro. CD93/C1qR, a receptor expressed during early B-cell development, is reinduced during plasma-cell differentiation. High CD93/CD138 expression was restricted to antibody-secreting cells both in T-dependent and T-independent responses as naive, memory, and germinal-center B cells remained CD93-negative. CD93 was expressed on (pre)plasmablasts/plasma cells, including long-lived plasma cells that showed decreased cell cycle activity, high levels of isotype-switched Ig secretion, and modification of the transcriptional network. CD93 is important for the maintenance of plasma cells in bone marrow niches.