Related Products

Molecular

Species

Protein

Antibody

Application

cDNA ORF Clone  
Cell Lysate  
qPCR

  PD-L1    

B7-H1  CD274

Mouse

50010-M03H
C-His&C-human IgG1-Fc   Active

/

/

50010-M02H
C-human IgG1-Fc

/

/

50010-M08H
C-His&Active

50010-RP01
Rabbit IgG Pab

ELISA

50010-RP02
Rabbit IgG Pab      

Antigen Affinity Purified

ELISA

50010-R401
Rabbit IgG Mab

FCM

50010-R485
Rabbit IgG Mab

FCM,IF,ICC/IF

Canine

70110-D02H
C-human IgG1-Fc

/

/

Cynomolgus

90251-C02H
C-human IgG1-Fc

/

/

90251-C08H
C-His

90251-T48
Rabbit IgG Pab     

Antigen Affinity Purified

ELISA,WB

Rat

80450-R02H
C-human IgG1-Fc

/

/

80450-R08H
C-His

/

/

Human

10084-H02H
C-human IgG1-Fc&Active

/

/

10084-H08H
C-His&Active

10084-R639
Rabbit IgG Blocking Antibody

B/N

10084-MB55
Mouse IgG1 Mab

IHC-P

10084-R015
Rabbit IgG Mab

ELISA,IHC-P

10084-RP01
Rabbit IgG Pab

ELISA

10084-MM13
Mouse IgG1 Mab

ELISA

10084-T24
Rabbit IgG Pab     

Antigen Affinity Purified

ELISA,IHC-P

10084-H08H-B
C-His&Active

/

/

10084-H05H
C-mouse IgG1-Fc

/

/

Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain, and together with PD-L2, are t,,wo ligands for PD1 which belongs to the CD28/CTLA4 family expressed on activated lymphoid cells. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression.Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.