Related Products

Molecular

Species

Protein

Antibody

Application

cDNA ORF Clone
Immunomagnetic Beads 
qPCR
ELISA Pair Set

Galectin-1

Mouse

50100-MNAE
Native&Active

50100-RP01
Rabbit IgG Pab

ELISA

Human

10290-HNAE
Native&Active

10290-R001
Rabbit IgG MAb

WB,IP

10290-RP02
Rabbit IgG PAb,Antigen Affinity Purified

ELISA,WB

10290-MM01
Mouse IgG1 Mab

IHC-P

10290-MM04
Mouse IgG1 Mab

ELISA

10290-R008
Rabbit IgG Mab

ELISA

10290-RP01
Rabbit IgG PAb

ELISA

Rat

80248-RNAE
Native

80248-RP01
Rabbit IgG Pab

ELISA

80248-T52
Rabbit IgG PAb,Antigen Affinity Purified

ELISA,WB,IP

80248-MM06
Mouse IgG1 Mab

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Galectin-1 (Gal-1, GAL1), is a member of the galectins, a family of animal lectins ranging from Caenorhabditis elegans to humans, which is defined by their affinity for beta-galactosides and by significant sequence similarity in the carbohydrate-binding site. It is a homodimer with a subunit molecular mass of 14.5 kDa, which contains six cysteine residues per subunit. The cysteine residues should be in a free state in order to maintain a molecular structure that is capable of showing lectin activity. This endogenous lectin widely expressed at sites of inflammation and tumour growth, has been postulated as an attractive immunosuppressive agent to restore immune cell tolerance and homeostasis in autoimmune and inflammatory settings. On the other hand, galectin-1 contributes to different steps of tumour progression including cell adhesion, migration and tumour-immune escape, suggesting that blockade of galectin-1 might result in therapeutic benefits in cancer. Several potential glycoprotein ligands for galectin-1 have been identified, including lysosome-associated membrane glycoproteins and fibronectin, laminin, as well as T-cell glycoproteins CD43 and CD45. Evidence points to Gal-1 and its ligands as one of the master regulators of such immune responses as T-cell homeostasis and survival, T-cell immune disorders, inflammation and allergies as well as host-pathogen interactions.