Related Products

Molecular

Species

Protein

Antibody

Application

cDNA ORF Clone  
Cell Lysate  
qPCR

EphA2

Mouse

50586-M08H
C-His,Active

50586-R101-F
Rabbit IgG Mab(FITC)

FCM

50586-RP01
Rabbit IgG Pab

ELISA

50586-R301-F
Rabbit IgG Mab(FITC)

FCM

50586-R101
Rabbit IgG Mab

FCM

50586-R101-P
Rabbit IgG Mab(PE)

FCM

50586-RP02
Rabbit IgG PAb,Antigen Affinity Purified

ELISA

50586-R101-A
Rabbit IgG Mab

/

50586-R301
Rabbit IgG Mab

ELISA,FCM

50586-R301-P
Rabbit IgG Mab(PE)

FCM

Rat

80110-R02H
C-human IgG1-Fc

/

/

Human

13926-H20B1
N-GST&C-His(aa585-976)

13926-T16
Rabbit IgG PAb,Antigen Affinity Purified

ELISA

13926-H08H
C-His

/

/

Eph receptor A2 (Ephrin type-A receptor 2 or EphA2) is a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. The Eph receptors' corresponding family of ligands are the ephrins anchored to cell surfaces. The ephrins and Eph receptors are implicated as positional labels that may guide the development of neural topographic maps. They have also been found implicated in embryonic patterning, neuronal targeting, vascular development and adult neovascularization. The large family of ligands and receptors may make a major contribution to the accurate spatial patterning of connections and cell position in the nervous system. Furthermore, elevated expression of Eph receptors and ephrin ligands is associated with tumors and associated tumor vasculature, suggesting the Eph receptors and ephrin ligands also play critical roles in tumor angiogenesis and tumor growth. Unlike most Eph kinases, which are primarily expressed during development, EphA2 is primarily found in adult human epithelial cells. The cellular functions of EphA2 may be regulating cell growth, survival, migration, and angiogenesis.Unlike other receptor tyrosine kinases, ligand binding is not necessary for EphA2. Rather, the ligand appears to regulate EphA2 subcellular localization and its interactions with downstream adapter and signaling proteins. Eph receptor A2(EphA2) has been demonstrated to critically regulate tumor cell growth, migration and invasiveness. Eph receptor A2(EphA2) is frequently overexpressed and functionally altered in aggressive tumor cells, and that these changes promote metastatic character.