Related Products

Molecular

Species

Protein

Antibody

Application

cDNA ORF Clone  
Cell Lysate  
qPCR
ELISA Pair Set
Immunomagnetic Beads

IL6R

Mouse

50280-M08H
C-His

50280-RP02
Rabbit IgG Pab,Antigen Affinity Purified

ELISA,WB

50280-RP01
Rabbit IgG Pab

ELISA

50280-R033
Rabbit IgG Mab

FCM,IF,ICC/IF

50280-R033-A
Rabbit IgG Mab(APC)

FCM

50280-R005
Rabbit IgG Mab

ELISA

Canine

70117-D08H
C-His

/

/

Rhesus

90324-C08H
C-His

/

/

Rat

81072-R08H
C-His

81072-T48
Rabbit IgG Pab,Antigen Affinity Purified

ELISA,WB

81072-R02H
C-human IgG1-Fc

/

/

Human

10398-H08H
C-His

10398-MM01
Mouse IgG1 Mab

ELISA

10398-RP02
Rabbit IgG Pab

ELISA

10398-T16
Rabbit IgG Pab,Antigen Affinity Purified

ELISA

10398-MM18
Mouse IgG1 Mab

IF,ICC/IF

10398-MM08
Mouse IgG1 Neutralizing Antibody

B/N

10398-RP03
Rabbit IgG Pab,Antigen Affinity Purified

ELISA

Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (sIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a sIL-6R protein are able to mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signalling. Through this so-called 'trans-signalling' mechanism, IL-6 is able to stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and sIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.