Related Products

Molecular

Species

Protein

Antibody

Application

cDNA ORF Clone 
qPCR 
Cell Lysate  
ELISA Pair Set 

IL4

Mouse

51084-MNAE
Native

51084-R015
Rabbit IgG Mab

ELISA

51084-M08B
C-His&Active

/

/

Canine

70021-DNAE
Native

70021-RP01
Rabbit IgG Pab

ELISA

Human

GMP-11846-HNAE
Native

/

/

11846-HNAE
Native&Active

11846-R101
Rabbit IgG Mab

ELISA

11846-MM05
Rabbit IgG Mab

FCM

11846-T16
Rabbit IgG Pab,Antigen Affinity Purified

ELISA

11846-MM04
Rabbit IgG Mab

/

11846-RP01
Rabbit IgG Pab

ELISA

Interleukin-4, also known as IL4, is a secreted protein which belongs to the IL-4 / IL-13 family. Interleukin-4 / IL4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation. It enhances both secretion and cell surface expression of IgE and IgG1. Interleukin-4 / IL4 also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Interleukin-4 is essential for the switching of B cells to IgE antibody production and for the maturation of T helper (Th) cells toward the Th2 phenotype. It participates in at least several B-cell activation processes as well as of other cell types. However, studies show that double mutant (Q116D, Y119D) of the murine IL4 protein (QY), both glutamine 116 and tyrosine 119, which binds to the IL4 receptor alpha, completely inhibites in a dose-dependent manner the IL4-induced proliferation of lipopolysaccharide-stimulated murine splenic B-cells, of the murine T cell line CTLL-2, and of the murine pre-B-cell line BA/F3. QY also inhibited the IL4-stimulated up-regulation of CD23 expression by lipopolysaccharide-stimulated murine splenic B-cells and abolished tyrosine phosphorylation of the transcription factor Stat6 and the tyrosine kinase Jak3 in IL4-stimulated BA/F3 cells.