Related Products

Molecular

Species

Protein

Antibody

Application

cDNA ORF Clone  
Cell Lysate  
qPCR

IL1R3

Mouse

52657-M08H
C-His

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52657-M02H
C-human IgG1-Fc

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Human

10121-H08H
C-His

10121-RP01
Rabbit IgG Pab

ELISA

10121-MM05-F
Mouse IgG2a Mab(FITC)

FCM

10121-MM05-P
Mouse IgG2a Mab(PE)

FCM

10121-MM05-A
Mouse IgG2a Mab(APC)

FCM

10121-MM04
Mouse IgG1 Mab

ELISA

10121-MM05
Mouse IgG2a Mab

ELISA,FCM

10121-RP02
Rabbit IgG PAb,Antigen Affinity Purified

ELISA

10121-T48
Rabbit IgG PAb,Antigen Affinity Purified

ELISA,WB

10121-H03H
C-human IgG1-Fc&His

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Interleukin-1 receptor accessory protein (IL-1RAcP) also known as Interleukin-1 receptor member 3 (IL-1R3) is a a cytokine receptor which binds interleukin 1. The IL-1 receptor accessory protein (IL1RAP) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction. Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. IL-1RAcP/IL-1R3 is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. IL-1RAcP/IL-1R3 mediates interleukin-1-dependent activation of NF-kappa-B. Isoform 1 is part of the membrane-bound form of the IL-1 receptor. Signaling involves formation of a ternary complex containing IL1R1, TOLLIP, MYD88, and IRAK1 or IRAK2. Isoform 2 modulates the response to interleukins by associating with soluble IL1R1 and enhancing interleukin-binding to the decoy receptor.