Related Products

Molecular

Species

Protein

Antibody

Application

cDNA ORF Clone
Cell Lysate 
qPCR

VEGFR2/CD309

Human

10012-H02H1
C-human IgG1-Fc

/

/

10012-H02H
C-human IgG1-Fc&Active

/

/

10012-H20B1
N-GST & His

/

/

10012-H02H2
C-human IgG1-Fc

/

/

10012-H08H2
C-His

/

/

10012-H08H3
C-His

/

/

10012-H08H-B
C-His&Active

/

/

10012-H08H1
C-His

/

/

10012-H08H
C-His&Active

10012-R002
Rabbit IgG MAb

ELISA

10012-MM03-P
Mouse IgG1 MAb(PE)

ELISA

10012-MM06
Mouse IgG1 MAb

/

10012-R001
Rabbit IgG MAb

FCM

10012-MM03
Mouse IgG1 MAb

/

10012-RP01
Rabbit IgG PAb

ELISA

10012-MM06-P
Mouse IgG1 MAb

ELISA

10012-MM03-F
Mouse IgG1 MAb(FITC)

FCM

10012-T24
Rabbit IgG PAb, Antigen Affinity Purified

ELISA,IHC-P

Mouse

50998-M08H
C-His

50998-R004-P
Rabbit IgG MAb(PE)

FCM

50998-R001-A
Rabbit IgG MAb(APC)

FCM

50998-R004-A
Rabbit IgG MAb(APC)

FCM

50998-R004
Rabbit IgG MAb

FCM

50998-T16
Rabbit IgG PAb, Antigen Affinity Purified

ELISA

50998-R093
Rabbit IgG MAb

ELISA

50998-R036
Rabbi,,t IgG MAb

/

50998-R001-P
Rabbit IgG MAb

FCM

50998-R001
Rabbit IgG MAb

FCM

50998-RP01
Rabbit IgG PAb

ELISA

50998-M08H-B
C-His

/

/

50998-M02H
C-human IgG1-Fc

50956-R001-F
Rabbit IgG MAb(FITC)

FCM

Rat

80113-R02H
C-human IgG1-Fc

80270-R001
Rabbit IgG MAb

ELISA

80113-R08H
C-His

80113-RP01
Rabbit IgG PAb

ELISA

80113-T16
Rabbit IgG PAb,Antigen Affinity Purified

ELISA

VEGFR2, also called as KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be the primary signal transducer for angiogenesis and the development of pathological conditions such as cancer and diabetic retinopathy. It has been shown that VEGFR2 is expressed mainly in the endothelial cells, and the expression is upregulated in the tumor vasculature. Thus the inhibition of VEGFR2 activity and its downstream signaling are important targets for the treatment of diseases involving angiogenesis. VEGFR2 transduces the major signals for angiogenesis via its strong tyrosine kinase activity. However, unlike other representative tyrosine kinase receptors, VEGFR2 does not use the Ras pathway as a major downstream signaling but rather uses the phospholipase C-protein kinase C pathway to signal mitogen-activated protein (MAP)-kinase activation and DNA synthesis. VEGFR2 is a direct and major signal transducer for pathological angiogenesis, including cancer and diabetic retinopathy, in cooperation with many other signaling partners; thus, VEGFR2 and its downstream signaling appear to be critical targets for the suppression of these diseases. VEGF and VEGFR2-mediated survival signaling is critical to endothelial cell survival, maintenance of the vasculature and alveolar structure and regeneration of lung tissue. Reduced VEGF and VEGFR2 expression in emphysematous lungs has been linked to increased endothelial cell death and vascular regression.