Related Products

Molecular

Species

Protein

Antibody

Application

cDNA ORF Clone 
Cell Lysate 
qPCR 

PD-L2

Human

10292-H02H
C-human IgG1-Fc

/

/

10292-H08H-B
C-His

/

/

10292-H08H
C-His&Active

10292-RP02
Rabbit IgG Pab,Antigen Affinity Purified

ELISA

10292-R018
Rabbit IgG Mab

ELISA,WB

10292-R002-F
Rabbit IgG Mab

FCM

10292-RP01
Rabbit IgG Pab

ELISA

10292-H03H
C-human IgG1-Fc&His Active

/

/

Cynomolgus

90249-C08H
C-His

/

/

90249-C02H
C-human IgG1-Fc

/

/

Rat

80454-R02H
C-human IgG1-Fc

/

/

80454-R08H
C-His

/

/

Mouse

50804-M02H
C-human IgG1-Fc  Active

/

/

50804-M08H
C-His&Active

50804-RP01
Rabbit IgG Pab

ELISA

50804-T16
Rabbit IgG Pab,Antigen Affinity Purified

ELISA

Programmed death ligand 2 (PD-L2), also referred to as B7-DC and CD273, is a member of the B7 family of proteins including B7-1, B7-2, B7-H2, B7-H1 (PD-L1), and B7-H3. PD-L2 is a type I membrane protein and structurally consists of an extracellular region containing one V-like and one C-like Ig domain, a transmembrane region, and a short cytoplasmic domain. PD-L2 is expressed on antigen presenting cells, placental endothelium and medullary thymic epithelial cells, and can be induced by LPS in B cells, INF-γ in monocytes, or LPS plus IFN-γ in dendritic cells. The CD28 and B7 protein families are critical regulators of immune responses. PD-L2 and PD-L1 are two ligands for PD-1, member of the CD28/CTLA4 family expressed on activated lymphoid cells, and thus provide signals for regulating T cell activation and immune tolerance. The interaction of B7-DC/PD-1 exhibited a 2-6-fold higher affinity compared with the interaction of B7-H1/PD-1.