Related Products

Molecular

Species

Protein

Antibody

Application

cDNA ORF Clone  
Cell Lysate  
qPCR
ELISA Pair Set
Immunomagnetic Beads

OSMR/IL31RB

Mouse

50500-M08H
C-His

50500-T16
Rabbit IgG Pab,Antigen Affinity Purified

ELISA

50500-RP01
Rabbit IgG Pab

ELISA

50500-R202
Rabbit IgG Mab

ELISA

Human

11226-H08H
C-His

11226-R007
Rabbit IgG Mab

ELISA

11226-MM01
Mouse IgG1 Mab

ELISA,IP

11226-R002-P
Rabbit IgG Mab(PE)

FCM

11226-R002
Rabbit IgG Mab

FCM

11226-RP02
Rabbit IgG PAb,Antigen Affinity Purified

ELISA,WB

11226-RP01
Rabbit IgG Pab

ELISA

11226-R002-A
Rabbit IgG Mab(APC)

FCM

Oncostatin-M specific receptor subunit beta also known as the oncostatin M receptor (OSMR) and Interleukin-31 receptor subunit beta (IL-31RB), is one of the receptor proteins for oncostatin M. OSMR is a member of the type I cytokine receptor family. IL-31RB/OSMR heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in IL-31RB/OSMR have been associated with familial primary localized cutaneous amyloidosis. Defects in IL-31RB/OSMR are the cause of amyloidosis primary localized cutaneous type 1 (PLCA1), also known as familial lichen amyloidosis or familial cutaneous lichen amyloidosis. PLCA1 is a hereditary primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening (lichenification) that may be exacerbated by chronic scratching and rubbing. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins.