Related Products

Molecular

Species

Protein

Antibody

Application

cDNA ORF Clone 
Cell Lysate
qPCR
ELISA Kit
ELISA Pair Set 
Immunomagnetic Beads 

UPAR

Human

10925-H08H
C-His&Active

10925-RP01
Rabbit IgG Pab

ELISA

10925-MM08
Mouse IgG1 Mab

ELISA

10925-R103
Rabbit IgG Mab

ELISA

10925-RP02
Rabbit IgG PAb,Antigen Affinity Purified

ELISA,IP

10925-MM05T
Mouse IgG1 Mab

FCM

Mouse

50160-M08H
C-His

50160-RP02
Rabbit IgG PAb,Antigen Affinity Purified

ELISA

50160-R014
Rabbit IgG Mab

ELISA

50160-RP01
Rabbit IgG Pab

ELISA

50160-M03H
C-human IgG1-Fc&His Active

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Urokinase plasminogen activator (uPA) and/or its receptor (uPAR) are essential for metastasis, and overexpression of these molecules is strongly correlated with poor prognosis in a variety of malignant tumours. uPAR and uPA levels in both resected tumor tissue and plasma are of independent prognostic significance for patient survival in several types of human cancer. This system has classically been thought to drive tumor progression by mediating directed extracellular proteolysis on the surface of migrating or invading cells, and intervening with this proteolysis by targeting uPAR has been proposed to represent a novel approach for inhibiting tumor progression. uPAR, also known as PLAUR or CD87, has been implicated in the growth, metastasis, and angiogenesis of several solid and hemotologic malignancies. uPAR is a highly glycosylated, 55-60kDa integral membrane protein linked to the plasma membrane by a glycosylphosphatidylinositol (GPI) anchor. It is part of a cell surface system that also consists of the serine protease uPA and several specific inhibitors (plasminogen activator inhibitors 1 and 2). Additionally, the analysis of CD87 (urokinase-type plasminogen activator receptor - uPAR) expression has a potential role in the diagnostic or prognostic work-up of several hematological malignancies, particularly acute leukemia and multiple myeloma.