Related Products

Molecular

Species

Protein

Antibody

Application

cDNA ORF Clone 
Cell Lysate  
qPCR 
Immunomagnetic Beads 

SERPINF1

Human

11104-H08H
C-His

11104-RP01
Rabbit IgG PAb

ELISA

11104-R013
Rabbit IgG MAb

ELISA

11104-R033
Rabbit IgG MAb

WB

11104-RP02
Rabbit IgG PAb,Antigen Affinity Purified

ELISA,WB,IP

Rat

80481-R08H
C-His

80481-T16
Rabbit IgG PAb,Antigen Affinity Purified

ELISA

Mouse

50235-M08H
C-His

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Pigment epithelium-derived factor, also known as PEDF, Serpin F1, and SERPINF1, is a multiple functional protein which has both anti-angiogenic activity and neurotrophic activity at the same time. PEDF is a secreted glycoprotein that belongs to the noninhibitory serpin. It has an alpha/beta core serine-protease inhibitor domain, three major beta-sheets, and ten alpha-helices. PEDF does not inhibit either serine or cysteine proteinases. PEDF exerts diverse physiological activities including anti-angiogenesis, anti-vasopermeability, anti-tumor, and neurotrophic activities. PEDF acts via multiple high affinity ligands and cell receptors. It has been described as a natural angiogenesis inhibitor with neurotrophic and immune-modulation properties. PEDF induces macrophages apoptosis and necrosis through the activation of peroxisome proliferator-activated receptor-gamma by which PEDF could modulate inflammatory reactions in septic shock. It balances angiogenesis in the eye and blocks tumor progression.