Related Products

Molecular

Species

Protein

Antibody

Application

cDNA ORF Clone 
Cell Lysate 
qPCR 
Immunomagnetic Beads 

TGFbeta1

Mouse

50698-M08H
C-His

50698-RP01
Rabbit IgG Pab

ELISA

50698-T48
Rabbit IgG PAb,Antigen Affinity Purified

ELISA,WB

Canine

70087-D08H
C-His

70087-T52
Rabbit IgG PAb,Antigen Affinity Purified

ELISA,WB,IP

Cynomolgus

90294-C08H
C-His

90294-RP01
Rabbit IgG Pab

ELISA

90294-T16
Rabbit IgG PAb,Antigen Affinity Purified

ELISA

Rat

80116-R08H
C-His

/

/

80116-RNAH
Native

/

/

Human

10804-H08H
C-His,Active

10804-T52
Rabbit IgG PAb,Antigen Affinity Purified

ELISA,WB,IP

10804-HNAC
Native,Active

/

/

10804-H08H1
C-His

/

/

TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, differentiation, motility, adhesion and death. TGF-beta 1 positively and negatively regulates many other growth factors. It inhibits the secretion and activity of many other cytokines including interferon-γ, tumor necrosis factor-alpha and various interleukins. It can also decrease the expression levels of cytokine receptors. Meanwhile, TGF-beta 1 also increases the expression of certain cytokines in T cells and promotes their proliferation, particularly if the cells are immature. TGF-beta 1 also inhibits proliferation and stimulates apoptosis of B cells, and plays a role in controlling the expression of antibody, transferrin and MHC class II proteins on immature and mature B cells. As for myeloid cells, TGF-beta 1can inhibit their proliferation and prevent their production of reactive oxygen and nitrogen intermediates. However, as with other cell types, TGF-beta 1 also has the opposite effect on cells of myeloid origin. TGF-beta 1 is a multifunctional protein that controls proliferation, differentiation and other functions in many cell types. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Once cells lose their sensitivity to TGF-beta1-mediated growth inhibition, autocrine TGF-beta signaling can promote tumorigenesis. Elevated levels of TGF-beta1 are often observed in advanced carcinomas, and have been correlated with increased tumor invasiveness and disease progression.