Related Products

Molecular

Species

Protein

Antibody

Application

cDNA ORF Clone
Cell Lysate
ELISA Kit 
ELISA Pair Set
Immunomagnetic Beads 
qPCR

TIM-3/HAVCR2

Mouse

51152-M08H
C-His

51152-T52
Rabbit IgG Pab,Antigen Affinity Purified

ELISA,WB,IP

51152-RP01
Rabbit IgG Pab

ELISA

51152-M02H
C-human IgG1-Fc

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Human

10390-H03H
C-human IgG1-Fc&His

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10390-H08H
C-His

10390-RP01
Rabbit IgG Pab

ELISA

10390-RP02
Rabbit IgG Pab,Antigen Affinity Purified

ELISA

10390-MM04
Mouse IgG2b Mab

ELISA

10390-R024
Rabbit IgG Mab

ELISA

Cynomolgus

90312-C02H
C-human IgG1-Fc

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Hepatitis A virus cellular receptor 2 (HAVCR2), formerly known as T cell immunoglobulin and mucin domain-3 (TIM-3), is a transmembrane glycoprotein expressed on the surface of terminally differentiated Th1 cells but not on Th2 cells. It was the first surface molecule that specifically identifies Th1 cells in both mice and human. Recently, identification of Galectin-9 as a ligand for TIM-3 has established the TIM-3-Galectin-9 pathway as an important regulator of Th1 immunity and tolerance induction. Engagement of Tim-3 by its ligand galectin-9 negatively regulates IFN-gamma secretion and influences the ability to induce T cell tolerance in both mice and man. It suggests a novel paradigm in which dysregulation of the TIM-3-galectin-9 pathway could underlie chronic autoimmune disease states, such as multiple sclerosis. Recent work has explored the role of TIM-3 in systemic lupus erythematosus (SLE), and their results indicate that TIM-3 may represent a novel target for the treatment of SLE. Numerous studies have demonstrated that Tim-3 influences autoimmune diseases, including diabetes and multiple sclerosis, and its role in other inflammatory diseases including allergies and cancer is beginning to become clear. In tumor rejection model, soluble form of Tim-3 (sTim-3) significantly impaired T cell antitumor immunity, evidenced by decreased antitumor CTL activity and reduced amount of tumor-infiltrating lymphocytes in tumor. sTim-3 as an immunoregulatory molecule that may be involved in the negative regulation of T cell-mediated immune response。